Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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AD Lung Beer Cluster Number 32 (147 genes) This page contains all miRNA mediated regulation and functional enrichment for AD Lung Beer cluster number 32. Information about lung cancer can be found on Wikipedia, and further information about the "AD Lung Beer" dataset can be found in Beer et al., 2002. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan zzz999 hsa-mir-656 zzz999 Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0001525 angiogenesis 10 GO:0001568 blood vessel development 17 GO:0001570 vasculogenesis 5 GO:0001775 cell activation 22 GO:0001816 cytokine production 10 GO:0001944 vasculature development 17 GO:0002376 immune system process 43 GO:0002576 platelet degranulation 7 GO:0002673 regulation of acute inflammatory response 4 GO:0002682 regulation of immune system process 24 GO:0002684 positive regulation of immune system process 18 GO:0002687 positive regulation of leukocyte migration 4 GO:0002694 regulation of leukocyte activation 12 GO:0002696 positive regulation of leukocyte activation 9 GO:0003012 muscle system process 10 GO:0003013 circulatory system process 12 GO:0006897 endocytosis 11 GO:0006898 receptor-mediated endocytosis 6 GO:0006928 cellular component movement 26 GO:0006950 response to stress 55 GO:0006952 defense response 30 GO:0006954 inflammatory response 19 GO:0006955 immune response 24 GO:0006959 humoral immune response 6 GO:0007165 signal transduction 58 GO:0007166 cell surface receptor linked signaling pathway 36 GO:0007275 multicellular organismal development 58 GO:0007565 female pregnancy 7 GO:0007566 embryo implantation 4 GO:0007585 respiratory gaseous exchange 5 GO:0007596 blood coagulation 18 GO:0007599 hemostasis 19 GO:0008015 blood circulation 12 GO:0008283 cell proliferation 31 GO:0008285 negative regulation of cell proliferation 15 GO:0009605 response to external stimulus 29 GO:0009611 response to wounding 38 GO:0009617 response to bacterium 9 GO:0009653 anatomical structure morphogenesis 37 GO:0009719 response to endogenous stimulus 18 GO:0009725 response to hormone stimulus 17 GO:0009790 embryo development 17 GO:0009887 organ morphogenesis 18 GO:0010324 membrane invagination 11 GO:0010573 vascular endothelial growth factor production 3 GO:0010574 regulation of vascular endothelial growth factor production 3 GO:0014070 response to organic cyclic compound 9 GO:0016192 vesicle-mediated transport 19 GO:0016477 cell migration 22 GO:0030154 cell differentiation 38 GO:0030168 platelet activation 12 GO:0030334 regulation of cell migration 11 GO:0030335 positive regulation of cell migration 8 GO:0031347 regulation of defense response 13 GO:0031348 negative regulation of defense response 5 GO:0031623 receptor internalization 4 GO:0031960 response to corticosteroid stimulus 9 GO:0032101 regulation of response to external stimulus 15 GO:0032501 multicellular organismal process 81 GO:0032502 developmental process 64 GO:0032879 regulation of localization 21 GO:0040011 locomotion 30 GO:0040012 regulation of locomotion 12 GO:0042060 wound healing 22 GO:0042127 regulation of cell proliferation 27 GO:0042221 response to chemical stimulus 57 GO:0043112 receptor metabolic process 6 GO:0045123 cellular extravasation 3 GO:0045444 fat cell differentiation 6 GO:0045595 regulation of cell differentiation 17 GO:0048513 organ development 38 GO:0048514 blood vessel morphogenesis 14 GO:0048518 positive regulation of biological process 48 GO:0048519 negative regulation of biological process 41 GO:0048522 positive regulation of cellular process 42 GO:0048545 response to steroid hormone stimulus 10 GO:0048568 embryonic organ development 11 GO:0048583 regulation of response to stimulus 38 GO:0048646 anatomical structure formation involved in morphogenesis 17 GO:0048731 system development 53 GO:0048856 anatomical structure development 56 GO:0048870 cell motility 23 GO:0050727 regulation of inflammatory response 11 GO:0050728 negative regulation of inflammatory response 4 GO:0050817 coagulation 18 GO:0050863 regulation of T cell activation 8 GO:0050865 regulation of cell activation 14 GO:0050866 negative regulation of cell activation 5 GO:0050867 positive regulation of cell activation 10 GO:0050870 positive regulation of T cell activation 7 GO:0050873 brown fat cell differentiation 4 GO:0050878 regulation of body fluid levels 19 GO:0050896 response to stimulus 102 GO:0050900 leukocyte migration 13 GO:0051150 regulation of smooth muscle cell differentiation 3 GO:0051239 regulation of multicellular organismal process 28 GO:0051249 regulation of lymphocyte activation 10 GO:0051251 positive regulation of lymphocyte activation 8 GO:0051270 regulation of cellular component movement 13 GO:0051272 positive regulation of cellular component movement 9 GO:0051384 response to glucocorticoid stimulus 9 GO:0051385 response to mineralocorticoid stimulus 3 GO:0051412 response to corticosterone stimulus 3 GO:0051674 localization of cell 23 GO:0065007 biological regulation 100 GO:0065008 regulation of biological quality 48 GO:0070374 positive regulation of ERK1 and ERK2 cascade 4 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-656 PITA GO:0001525 angiogenesis 3 10 147 16 0.01345149 hsa-mir-656 PITA GO:0001568 blood vessel development 6 17 147 16 0.0004826717 hsa-mir-656 PITA GO:0001570 vasculogenesis 2 5 147 16 0.00938394 hsa-mir-656 PITA GO:0001775 cell activation 2 22 147 16 0.4410159 hsa-mir-656 PITA GO:0001816 cytokine production 0 10 147 16 0.696248 hsa-mir-656 PITA GO:0001944 vasculature development 6 17 147 16 0.0004826717 hsa-mir-656 PITA GO:0002376 immune system process 6 43 147 16 0.1450845 hsa-mir-656 PITA GO:0002576 platelet degranulation 0 7 147 16 0.5616163 hsa-mir-656 PITA GO:0002673 regulation of acute inflammatory response 0 4 147 16 0.3725001 hsa-mir-656 PITA GO:0002682 regulation of immune system process 2 24 147 16 0.5054243 hsa-mir-656 PITA GO:0002684 positive regulation of immune system process 2 18 147 16 0.3081106 hsa-mir-656 PITA GO:0002687 positive regulation of leukocyte migration 0 4 147 16 0.3725001 hsa-mir-656 PITA GO:0002694 regulation of leukocyte activation 2 12 147 16 0.1263055 hsa-mir-656 PITA GO:0002696 positive regulation of leukocyte activation 1 9 147 16 0.2541619 hsa-mir-656 PITA GO:0003012 muscle system process 2 10 147 16 0.07927076 hsa-mir-656 PITA GO:0003013 circulatory system process 3 12 147 16 0.02752711 hsa-mir-656 PITA GO:0006897 endocytosis 1 11 147 16 0.3415012 hsa-mir-656 PITA GO:0006898 receptor-mediated endocytosis 1 6 147 16 0.1287436 hsa-mir-656 PITA GO:0006928 cellular component movement 6 26 147 16 0.009293271 hsa-mir-656 PITA GO:0006950 response to stress 6 55 147 16 0.3832815 hsa-mir-656 PITA GO:0006952 defense response 1 30 147 16 0.8821331 hsa-mir-656 PITA GO:0006954 inflammatory response 1 19 147 16 0.6465163 hsa-mir-656 PITA GO:0006955 immune response 2 24 147 16 0.5054243 hsa-mir-656 PITA GO:0006959 humoral immune response 0 6 147 16 0.5055032 hsa-mir-656 PITA GO:0007165 signal transduction 7 58 147 16 0.2576765 hsa-mir-656 PITA GO:0007166 cell surface receptor linked signaling pathway 7 36 147 16 0.01766984 hsa-mir-656 PITA GO:0007275 multicellular organismal development 11 58 147 16 0.002645774 hsa-mir-656 PITA GO:0007565 female pregnancy 1 7 147 16 0.1688244 hsa-mir-656 PITA GO:0007566 embryo implantation 0 4 147 16 0.3725001 hsa-mir-656 PITA GO:0007585 respiratory gaseous exchange 0 5 147 16 0.4427099 hsa-mir-656 PITA GO:0007596 blood coagulation 3 18 147 16 0.1109629 hsa-mir-656 PITA GO:0007599 hemostasis 4 19 147 16 0.03645935 hsa-mir-656 PITA GO:0008015 blood circulation 3 12 147 16 0.02752711 hsa-mir-656 PITA GO:0008283 cell proliferation 6 31 147 16 0.02682965 hsa-mir-656 PITA GO:0008285 negative regulation of cell proliferation 1 15 147 16 0.5067884 hsa-mir-656 PITA GO:0009605 response to external stimulus 3 29 147 16 0.3902146 hsa-mir-656 PITA GO:0009611 response to wounding 6 38 147 16 0.08040822 hsa-mir-656 PITA GO:0009617 response to bacterium 0 9 147 16 0.6564117 hsa-mir-656 PITA GO:0009653 anatomical structure morphogenesis 9 37 147 16 0.0008848022 hsa-mir-656 PITA GO:0009719 response to endogenous stimulus 2 18 147 16 0.3081106 hsa-mir-656 PITA GO:0009725 response to hormone stimulus 2 17 147 16 0.2752526 hsa-mir-656 PITA GO:0009790 embryo development 3 17 147 16 0.09270843 hsa-mir-656 PITA GO:0009887 organ morphogenesis 2 18 147 16 0.3081106 hsa-mir-656 PITA GO:0010324 membrane invagination 1 11 147 16 0.3415012 hsa-mir-656 PITA GO:0010573 vascular endothelial growth factor production 0 3 147 16 0.2940626 hsa-mir-656 PITA GO:0010574 regulation of vascular endothelial growth factor production 0 3 147 16 0.2940626 hsa-mir-656 PITA GO:0014070 response to organic cyclic compound 2 9 147 16 0.05952498 hsa-mir-656 PITA GO:0016192 vesicle-mediated transport 2 19 147 16 0.3413506 hsa-mir-656 PITA GO:0016477 cell migration 6 22 147 16 0.003105921 hsa-mir-656 PITA GO:0030154 cell differentiation 7 38 147 16 0.02519332 hsa-mir-656 PITA GO:0030168 platelet activation 1 12 147 16 0.3845403 hsa-mir-656 PITA GO:0030334 regulation of cell migration 4 11 147 16 0.002521649 hsa-mir-656 PITA GO:0030335 positive regulation of cell migration 4 8 147 16 0.0003746365 hsa-mir-656 PITA GO:0031347 regulation of defense response 1 13 147 16 0.426623 hsa-mir-656 PITA GO:0031348 negative regulation of defense response 1 5 147 16 0.09166102 hsa-mir-656 PITA GO:0031623 receptor internalization 1 4 147 16 0.05875019 hsa-mir-656 PITA GO:0031960 response to corticosteroid stimulus 1 9 147 16 0.2541619 hsa-mir-656 PITA GO:0032101 regulation of response to external stimulus 1 15 147 16 0.5067884 hsa-mir-656 PITA GO:0032501 multicellular organismal process 15 81 147 16 3.447409e-05 hsa-mir-656 PITA GO:0032502 developmental process 13 64 147 16 0.0001812071 hsa-mir-656 PITA GO:0032879 regulation of localization 5 21 147 16 0.01298269 hsa-mir-656 PITA GO:0040011 locomotion 6 30 147 16 0.02218437 hsa-mir-656 PITA GO:0040012 regulation of locomotion 4 12 147 16 0.004037131 hsa-mir-656 PITA GO:0042060 wound healing 5 22 147 16 0.01668647 hsa-mir-656 PITA GO:0042127 regulation of cell proliferation 5 27 147 16 0.04702109 hsa-mir-656 PITA GO:0042221 response to chemical stimulus 4 57 147 16 0.821926 hsa-mir-656 PITA GO:0043112 receptor metabolic process 1 6 147 16 0.1287436 hsa-mir-656 PITA GO:0045123 cellular extravasation 0 3 147 16 0.2940626 hsa-mir-656 PITA GO:0045444 fat cell differentiation 1 6 147 16 0.1287436 hsa-mir-656 PITA GO:0045595 regulation of cell differentiation 2 17 147 16 0.2752526 hsa-mir-656 PITA GO:0048513 organ development 6 38 147 16 0.08040822 hsa-mir-656 PITA GO:0048514 blood vessel morphogenesis 5 14 147 16 0.001141982 hsa-mir-656 PITA GO:0048518 positive regulation of biological process 7 48 147 16 0.101398 hsa-mir-656 PITA GO:0048519 negative regulation of biological process 6 41 147 16 0.1164285 hsa-mir-656 PITA GO:0048522 positive regulation of cellular process 7 42 147 16 0.04709947 hsa-mir-656 PITA GO:0048545 response to steroid hormone stimulus 1 10 147 16 0.2978847 hsa-mir-656 PITA GO:0048568 embryonic organ development 2 11 147 16 0.1016109 hsa-mir-656 PITA GO:0048583 regulation of response to stimulus 7 38 147 16 0.02519332 hsa-mir-656 PITA GO:0048646 anatomical structure formation involved in morphogenesis 7 17 147 16 4.327608e-05 hsa-mir-656 PITA GO:0048731 system development 11 53 147 16 0.0009620057 hsa-mir-656 PITA GO:0048856 anatomical structure development 12 56 147 16 0.0002615639 hsa-mir-656 PITA GO:0048870 cell motility 6 23 147 16 0.004192365 hsa-mir-656 PITA GO:0050727 regulation of inflammatory response 1 11 147 16 0.3415012 hsa-mir-656 PITA GO:0050728 negative regulation of inflammatory response 1 4 147 16 0.05875019 hsa-mir-656 PITA GO:0050817 coagulation 3 18 147 16 0.1109629 hsa-mir-656 PITA GO:0050863 regulation of T cell activation 1 8 147 16 0.2109093 hsa-mir-656 PITA GO:0050865 regulation of cell activation 2 14 147 16 0.1816639 hsa-mir-656 PITA GO:0050866 negative regulation of cell activation 1 5 147 16 0.09166102 hsa-mir-656 PITA GO:0050867 positive regulation of cell activation 1 10 147 16 0.2978847 hsa-mir-656 PITA GO:0050870 positive regulation of T cell activation 1 7 147 16 0.1688244 hsa-mir-656 PITA GO:0050873 brown fat cell differentiation 1 4 147 16 0.05875019 hsa-mir-656 PITA GO:0050878 regulation of body fluid levels 4 19 147 16 0.03645935 hsa-mir-656 PITA GO:0050896 response to stimulus 8 102 147 16 0.9292835 hsa-mir-656 PITA GO:0050900 leukocyte migration 3 13 147 16 0.0370391 hsa-mir-656 PITA GO:0051150 regulation of smooth muscle cell differentiation 1 3 147 16 0.03138828 hsa-mir-656 PITA GO:0051239 regulation of multicellular organismal process 1 28 147 16 0.8534566 hsa-mir-656 PITA GO:0051249 regulation of lymphocyte activation 1 10 147 16 0.2978847 hsa-mir-656 PITA GO:0051251 positive regulation of lymphocyte activation 1 8 147 16 0.2109093 hsa-mir-656 PITA GO:0051270 regulation of cellular component movement 4 13 147 16 0.006125129 hsa-mir-656 PITA GO:0051272 positive regulation of cellular component movement 4 9 147 16 0.000787864 hsa-mir-656 PITA GO:0051384 response to glucocorticoid stimulus 1 9 147 16 0.2541619 hsa-mir-656 PITA GO:0051385 response to mineralocorticoid stimulus 1 3 147 16 0.03138828 hsa-mir-656 PITA GO:0051412 response to corticosterone stimulus 1 3 147 16 0.03138828 hsa-mir-656 PITA GO:0051674 localization of cell 6 23 147 16 0.004192365 hsa-mir-656 PITA GO:0065007 biological regulation 12 100 147 16 0.1809349 hsa-mir-656 PITA GO:0065008 regulation of biological quality 7 48 147 16 0.101398 hsa-mir-656 PITA GO:0070374 positive regulation of ERK1 and ERK2 cascade 2 4 147 16 0.004026363

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